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Olaparib in the management of ovarian cancer

Alterations in the homologous repair pathway are thought to occur in 30%–50% of epithelial ovarian cancers. Cells deficient in homologous recombination rely on alternative pathways for DNA repair in order to survive, thereby providing a potential target for therapy. Olaparib, a poly(ADP-ribose) poly...

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Publicado en:Pharmgenomics Pers Med
Main Authors: Bixel, Kristin, Hays, John L
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538690/
https://ncbi.nlm.nih.gov/pubmed/26309417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S62809
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