Microbiota regulates type 1 diabetes through Toll-like receptors

Deletion of the innate immune adaptor myeloid differentiation primary response gene 88 (MyD88) in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D) results in microbiota-dependent protection from the disease: MyD88-negative mice in germ-free (GF), but not in specific pathogen-free con...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Burrows, Michael P., Volchkov, Pavel, Kobayashi, Koichi S., Chervonsky, Alexander V.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538618/
https://ncbi.nlm.nih.gov/pubmed/26216961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508740112
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