Influenza A(H7N9) Virus Acquires Resistance-Related Neuraminidase I222T Substitution When Infected Mallards Are Exposed to Low Levels of Oseltamivir in Water

Influenza A virus (IAV) has its natural reservoir in wild waterfowl, and new human IAVs often contain gene segments originating from avian IAVs. Treatment options for severe human influenza are principally restricted to neuraminidase inhibitors (NAIs), among which oseltamivir is stockpiled in prepar...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Gillman, Anna, Nykvist, Marie, Muradrasoli, Shaman, Söderström, Hanna, Wille, Michelle, Daggfeldt, Annika, Bröjer, Caroline, Waldenström, Jonas, Olsen, Björn, Järhult, Josef D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538561/
https://ncbi.nlm.nih.gov/pubmed/26077257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00886-15
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