Efficacy of the Clinical Agent VT-1161 against Fluconazole-Sensitive and -Resistant Candida albicans in a Murine Model of Vaginal Candidiasis

Vulvovaginal candidiasis (VVC) and recurrent VVC (RVVC) remain major health problems for women. VT-1161, a novel fungal CYP51 inhibitor which has potent antifungal activity against fluconazole-sensitive Candida albicans, retained its in vitro potency (MIC(50) of ≤0.015 and MIC(90) of 0.12 μg/ml) aga...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., Sobel, J. D., Lilly, E. A., Fidel, P. L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2015
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538529/
https://ncbi.nlm.nih.gov/pubmed/26124165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00185-15
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