Determination of [(11)C]Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice by Using Dynamic Positron Emission Tomography Bioimaging

Information about intralesional pharmacokinetics (PK) and spatial distribution of tuberculosis (TB) drugs is limited and has not been used to optimize dosing recommendations for new or existing drugs. While new techniques can detect drugs and their metabolites within TB granulomas, they are invasive...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: DeMarco, Vincent P., Ordonez, Alvaro A., Klunk, Mariah, Prideaux, Brendan, Wang, Hui, Zhuo, Zhang, Tonge, Peter J., Dannals, Robert F., Holt, Daniel P., Lee, Carlton K. K., Weinstein, Edward A., Dartois, Véronique, Dooley, Kelly E., Jain, Sanjay K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538528/
https://ncbi.nlm.nih.gov/pubmed/26169396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01146-15
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