Determination of [(11)C]Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice by Using Dynamic Positron Emission Tomography Bioimaging

Information about intralesional pharmacokinetics (PK) and spatial distribution of tuberculosis (TB) drugs is limited and has not been used to optimize dosing recommendations for new or existing drugs. While new techniques can detect drugs and their metabolites within TB granulomas, they are invasive...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: DeMarco, Vincent P., Ordonez, Alvaro A., Klunk, Mariah, Prideaux, Brendan, Wang, Hui, Zhuo, Zhang, Tonge, Peter J., Dannals, Robert F., Holt, Daniel P., Lee, Carlton K. K., Weinstein, Edward A., Dartois, Véronique, Dooley, Kelly E., Jain, Sanjay K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538528/
https://ncbi.nlm.nih.gov/pubmed/26169396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01146-15
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