Noninvasive (11)C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis

Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB), and key TB antimicrobials, including rifampin, have restricted brain penetration. A lack of reliable data on intralesional drug biodistribution in infected tissues has limited pharmacokinetic (PK) modeling efforts to optimize T...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Tucker, Elizabeth W., Guglieri-Lopez, Beatriz, Ordonez, Alvaro A., Ritchie, Brittaney, Klunk, Mariah H., Sharma, Richa, Chang, Yong S., Sanchez-Bautista, Julian, Frey, Sarah, Lodge, Martin A., Rowe, Steven P., Holt, Daniel P., Gobburu, Jogarao V. S., Peloquin, Charles A., Mathews, William B., Dannals, Robert F., Pardo, Carlos A., Kannan, Sujatha, Ivaturi, Vijay D., Jain, Sanjay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360528/
https://ncbi.nlm.nih.gov/pubmed/30518610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau0965
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