Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib-Mediated Amikacin Resistance in Klebsiella pneumoniae by Zinc and Copper Pyrithione

The in vitro activity of the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] was inhibited by CuCl(2) with a 50% inhibitory concentration (IC(50)) of 2.8 μM. The growth of an amikacin-resistant Klebsiella pneumoniae strain isolated from a neonate with meningitis was inhibited when amikaci...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Chiem, Kevin, Fuentes, Brooke A., Lin, David L., Tran, Tung, Jackson, Alexis, Ramirez, Maria S., Tolmasky, Marcelo E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538519/
https://ncbi.nlm.nih.gov/pubmed/26169410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01106-15
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