Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

[Image: see text] Diverse biological roles for mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) have necessitated the identification of potent inhibitors in order to study its function in various disease contexts. In particular, compounds that can be used to carry out such studies in...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Ndubaku, Chudi O., Crawford, Terry D., Chen, Huifen, Boggs, Jason W., Drobnick, Joy, Harris, Seth F., Jesudason, Rajiv, McNamara, Erin, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Vitorino, Philip, Wang, Lan, Wu, Ping, Yeung, Stacey, Chen, Jinhua, Chen, Kevin, Ding, Charles Z., Wang, Tao, Xu, Zijin, Gould, Stephen E., Murray, Lesley J., Ye, Weilan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538449/
https://ncbi.nlm.nih.gov/pubmed/26288693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00174
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