Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors

[Image: see text] The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric protein complex responsible for viral RNA transcription and replication, represents a primary target for antiviral drug development. One particularly attractive approach is interference with the endon...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Pala, Nicolino, Stevaert, Annelies, Dallocchio, Roberto, Dessì, Alessandro, Rogolino, Dominga, Carcelli, Mauro, Sanna, Vanna, Sechi, Mario, Naesens, Lieve
Format: Artigo
Language:Inglês
Published: American Chemical Society 2015
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538433/
https://ncbi.nlm.nih.gov/pubmed/26288686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00109
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