Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors

[Image: see text] We report the synthesis, biological evaluation, and structural study of a series of substituted heteroaryl-pyrazole carboxylic acid derivatives. These compounds have been developed as inhibitors of specific isoforms of carbonic anhydrase (CA), with potential as prototypes of a new...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Cadoni, Roberta, Pala, Nicolino, Lomelino, Carrie, Mahon, Brian P., McKenna, Robert, Dallocchio, Roberto, Dessì, Alessandro, Carcelli, Mauro, Rogolino, Dominga, Sanna, Vanna, Rassu, Mauro, Iaccarino, Ciro, Vullo, Daniela, Supuran, Claudiu T., Sechi, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601383/
https://ncbi.nlm.nih.gov/pubmed/28947941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00229
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