Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290

Relaxin peptide (RLN), which signals through the relaxin family peptide 1 (RXFP1) GPCR receptor, has shown therapeutic effects in an acute heart failure clinical trial. We have identified a small-molecule agonist of human RXFP1, ML290; however, it does not activate the mouse receptor. To find a suit...

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Publicat a:Front Endocrinol (Lausanne)
Autors principals: Huang, Zaohua, Myhr, Courtney, Bathgate, Ross A. D., Ho, Brian A., Bueno, Amaya, Hu, Xin, Xiao, Jingbo, Southall, Noel, Barnaeva, Elena, Agoulnik, Irina U., Marugan, Juan J., Ferrer, Marc, Agoulnik, Alexander I.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Endocrinology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538381/
https://ncbi.nlm.nih.gov/pubmed/26347712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2015.00128
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