Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition

The anticancer properties and mechanism of action of omega-3 polyunsaturated fatty acids (ω3-PUFAs) have been demonstrated in several cancers; however, the mechanism in lung cancer remains unclear. Here, we show that docosahexaenoic acid (DHA), a ω3-PUFA, induced apoptosis and autophagy in non-small...

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Veröffentlicht in:Biomed Res Int
Hauptverfasser: Kim, Nayeong, Jeong, Soyeon, Jing, Kaipeng, Shin, Soyeon, Kim, Soyeon, Heo, Jun-Young, Kweon, Gi-Ryang, Park, Seung-Kiel, Wu, Tong, Park, Jong-Il, Lim, Kyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538321/
https://ncbi.nlm.nih.gov/pubmed/26339598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/239764
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