The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-Mediated Akt-mTOR Signaling in Prostate Cancer Cells Expressing Mutant p53

Docosahexaenoic acid (DHA) induces autophagy-associated apoptotic cell death in wild-type p53 cancer cells via regulation of p53. The present study investigated the effects of DHA on PC3 and DU145 prostate cancer cell lines harboring mutant p53. Results show that, in addition to apoptosis, DHA incre...

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Detalhes bibliográficos
Main Authors: Shin, Soyeon, Jing, Kaipeng, Jeong, Soyeon, Kim, Nayeong, Song, Kyoung-Sub, Heo, Jun-Young, Park, Ji-Hoon, Seo, Kang-Sik, Han, Jeongsu, Park, Jong-Il, Kweon, Gi-Ryang, Park, Seung-Kiel, Wu, Tong, Hwang, Byung-Doo, Lim, Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691929/
https://ncbi.nlm.nih.gov/pubmed/23841076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/568671
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