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Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability
The Notch signalling pathway is fundamental to cell differentiation in developing and self-renewing tissues. Notch is activated upon ligand-induced conformational change of the Notch negative regulatory region (NRR), unmasking a key proteolytic site (S2) and facilitating downstream events. The favou...
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| Publicado no: | FEBS Open Bio |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4537882/ https://ncbi.nlm.nih.gov/pubmed/26288744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.07.006 |
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