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Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins
Microtubule (MT) dynamic instability is driven by GTP hydrolysis and regulated by microtubule-associated proteins, including the plus-end tracking end-binding protein (EB) family. We report six cryo-electron microscopy (cryo-EM) structures of MTs, at 3.5 Å or better resolution, bound to GMPCPP, GTPγ...
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| Publicat a: | Cell |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4537847/ https://ncbi.nlm.nih.gov/pubmed/26234155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.012 |
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