Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins

Microtubule (MT) dynamic instability is driven by GTP hydrolysis and regulated by microtubule-associated proteins, including the plus-end tracking end-binding protein (EB) family. We report six cryo-electron microscopy (cryo-EM) structures of MTs, at 3.5 Å or better resolution, bound to GMPCPP, GTPγ...

Full description

Saved in:
Bibliographic Details
Published in:Cell
Main Authors: Zhang, Rui, Alushin, Gregory M., Brown, Alan, Nogales, Eva
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537847/
https://ncbi.nlm.nih.gov/pubmed/26234155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.012
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items