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Integrating Single-Molecule Experiments and Discrete Stochastic Models to Understand Heterogeneous Gene Transcription Dynamics

The production and degradation of RNA transcripts is inherently subject to biological noise that arises from small gene copy numbers in individual cells. As a result, cellular RNA levels can exhibit large fluctuations over time and from one cell to the next. This article presents a range of precise...

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Publicat a:Methods
Autors principals: Munsky, Brian, Fox, Zachary, Neuert, Gregor
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537808/
https://ncbi.nlm.nih.gov/pubmed/26079925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2015.06.009
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