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Integrating Single-Molecule Experiments and Discrete Stochastic Models to Understand Heterogeneous Gene Transcription Dynamics
The production and degradation of RNA transcripts is inherently subject to biological noise that arises from small gene copy numbers in individual cells. As a result, cellular RNA levels can exhibit large fluctuations over time and from one cell to the next. This article presents a range of precise...
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| Udgivet i: | Methods |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4537808/ https://ncbi.nlm.nih.gov/pubmed/26079925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2015.06.009 |
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