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Somatic Rearrangement in B cells: It’s (mostly) Nuclear Physics
We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hotspots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.
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| Publicado en: | Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4537798/ https://ncbi.nlm.nih.gov/pubmed/26276627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.034 |
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