Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer

Polycomb repressive complex 2 (PRC2), which is responsible for the trimethylation of H3K27 (H3K27me3), plays a part in tumorigenesis, development and/or maintenance of adult tissue specificity. The pivotal role of PRC2 in cancer makes it a therapeutic target for epigenetic cancer therapy. However, n...

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Pubblicato in:Oncotarget
Autori principali: Chen, Huiming, Gao, Shijuan, Li, Jiandong, Liu, Dong, Sheng, Chunjie, Yao, Chen, Jiang, Wei, Wu, Jiaoxiang, Chen, Shuai, Huang, Wenlin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536998/
https://ncbi.nlm.nih.gov/pubmed/25944687
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