SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity

TANK-binding kinase 1 (TBK1)-mediated induction of type I interferon (IFN) plays a critical role in host antiviral responses and immune homeostasis. The negative regulation of TBK1 activity is largely unknown. We report that suppressor of cytokine signaling 3 (SOCS3) inhibits the IFN-β signaling pat...

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Pubblicato in:Mol Cell Biol
Autori principali: Liu, Dong, Sheng, Chunjie, Gao, Shijuan, Yao, Chen, Li, Jiandong, Jiang, Wei, Chen, Huiming, Wu, Jiaoxiang, Pan, Changchuan, Chen, Shuai, Huang, Wenlin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475924/
https://ncbi.nlm.nih.gov/pubmed/25939384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00090-15
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