Translating slow-binding inhibition kinetics into cellular and in vivo effects

Many drug candidates fail in clinical trials due to a lack of efficacy from limited target engagement or an insufficient therapeutic index. Minimizing off-target effects while retaining the desired pharmacodynamic (PD) response can be achieved by reduced exposure for drugs that display kinetic selec...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Chem Biol
मुख्य लेखकों: Walkup, Grant K., You, Zhiping, Ross, Philip L., Allen, Eleanor K. H., Daryaee, Fereidoon, Hale, Michael R., O’Donnell, John, Ehmann, David E., Schuck, Virna J. A., Buurman, Ed T., Choy, Allison L., Hajec, Laurel, Murphy-Benenato, Kerry, Marone, Valerie, Patey, Sara A., Grosser, Lena A., Johnstone, Michele, Walker, Stephen G., Tonge, Peter J., Fisher, Stewart L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536915/
https://ncbi.nlm.nih.gov/pubmed/25894085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1796
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