Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function

We previously reported on the importance of osteoactivin (OA/Gpnmb) in osteogenesis. In this study, we examined the role of OA in osteoclastogenesis, using mice with a nonsense mutation in the Gpnmb gene (D2J) and wild-type controls (D2J/Gpnmb(+)). In these D2J mice, micro-computed tomography and hi...

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Vydáno v:J Biol Chem
Hlavní autoři: Abdelmagid, Samir M., Sondag, Gregory R., Moussa, Fouad M., Belcher, Joyce Y., Yu, Bing, Stinnett, Hilary, Novak, Kimberly, Mbimba, Thomas, Khol, Matthew, Hankenson, Kurt D., Malcuit, Christopher, Safadi, Fayez F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536424/
https://ncbi.nlm.nih.gov/pubmed/25837253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624270
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