Mutation in Osteoactivin Decreases Bone Formation in Vivo and Osteoblast Differentiation in Vitro

We have previously identified osteoactivin (OA), encoded by Gpnmb, as an osteogenic factor that stimulates osteoblast differentiation in vitro. To elucidate the importance of OA in osteogenesis, we characterized the skeletal phenotype of a mouse model, DBA/2J (D2J) with a loss-of-function mutation i...

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Autori principali: Abdelmagid, Samir M., Belcher, Joyce Y., Moussa, Fouad M., Lababidi, Suzanne L., Sondag, Gregory R., Novak, Kimberly M., Sanyurah, Afif S., Frara, Nagat A., Razmpour, Roshanak, Del Carpio-Cano, Fabiola E., Safadi, Fayez F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2014
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Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936333/
https://ncbi.nlm.nih.gov/pubmed/24462663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.11.031
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