Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

Insulin-degrading enzyme (IDE, insulysin) is the best characterized catabolic enzyme implicated in proteolysis of insulin. Recently, a peptide inhibitor of IDE has been shown to affect levels of insulin, amylin, and glucagon in vivo. However, IDE(−/−) mice display variable phenotypes relating to fas...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Durham, Timothy B., Toth, James L., Klimkowski, Valentine J., Cao, Julia X. C., Siesky, Angela M., Alexander-Chacko, Jesline, Wu, Ginger Y., Dixon, Jeffrey T., McGee, James E., Wang, Yong, Guo, Sherry Y., Cavitt, Rachel Nicole, Schindler, John, Thibodeaux, Stefan J., Calvert, Nathan A., Coghlan, Michael J., Sindelar, Dana K., Christe, Michael, Kiselyov, Vladislav V., Michael, M. Dodson, Sloop, Kyle W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536412/
https://ncbi.nlm.nih.gov/pubmed/26085101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638205
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