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Robust sequence alignment using evolutionary rates coupled with an amino acid substitution matrix

BACKGROUND: Selective pressures at the DNA level shape genes into profiles consisting of patterns of rapidly evolving sites and sites withstanding change. These profiles remain detectable even when protein sequences become extensively diverged. A common task in molecular biology is to infer function...

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發表在:BMC Bioinformatics
Main Authors: Ndhlovu, Andrew, Hazelhurst, Scott, Durand, Pierre M.
格式: Artigo
語言:Inglês
出版: BioMed Central 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535666/
https://ncbi.nlm.nih.gov/pubmed/26269100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-015-0688-8
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