Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase**

Elaiophylin is an unusual C(2)-symmetric antibiotic macrodiolide produced on a bacterial modular polyketide synthase assembly line. To probe the mechanism and selectivity of diolide formation, we sought to reconstitute ring formation in vitro by using a non-natural substrate. Incubation of recombina...

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Bibliographic Details
Published in:Angew Chem Weinheim Bergstr Ger
Main Authors: Zhou, Yongjun, Prediger, Patrícia, Dias, Luiz Carlos, Murphy, Annabel C, Leadlay, Peter F
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2015
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Zuschriften
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535664/
https://ncbi.nlm.nih.gov/pubmed/26300568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ange.201500401
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