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Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition
This letter describes the on-going SAR efforts based on two scaffolds, a PLD1-biased piperidinyl benzimidazolone and a PLD2-biased piperidinyl triazaspirone, with the goal of enhancing PLD inhibitory potency and isoform selectivity. Here, we found that addition of an α-methyl moiety within the PLD2-...
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| Yayımlandı: | Bioorg Med Chem Lett |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4535313/ https://ncbi.nlm.nih.gov/pubmed/25466173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.11.017 |
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