Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad spectrum antiviral activity against influenza strains

Further chemical optimization of the halopemide-derived family of dual PLD1/2 inhibitors afforded ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC(50) >30,000 nM, cellular PLD2, IC(50) = 360 nM). Moreover, ML395 possesses an attractive in vitro DMPK...

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Enregistré dans:
Détails bibliographiques
Publié dans:ChemMedChem
Auteurs principaux: O’Reilly, Matthew C., Oguin, Thomas H., Scott, Sarah A., Thomas, Paul G., Locuson, Charles W., Morrison, Ryan D., Daniels, J. Scott, Brown, H. Alex, Lindsley, Craig W.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535312/
https://ncbi.nlm.nih.gov/pubmed/25210004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402333
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