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Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad spectrum antiviral activity against influenza strains
Further chemical optimization of the halopemide-derived family of dual PLD1/2 inhibitors afforded ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC(50) >30,000 nM, cellular PLD2, IC(50) = 360 nM). Moreover, ML395 possesses an attractive in vitro DMPK...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ChemMedChem |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4535312/ https://ncbi.nlm.nih.gov/pubmed/25210004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402333 |
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