Pharmacokinetics, biodistribution and metabolism of squalenoyl adenosine nanoparticles in mice using dual radio-labeling and radio-HPLC analysis

Adenosine is a pleiotropic endogenous nucleoside with potential neuroprotective pharmacological activity. However, clinical use of adenosine is hampered by its extremely fast metabolization. To overcome this limitation, we recently developed a new squalenoyl nanomedicine of adenosine [Squalenoyl-Ade...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Gaudin, Alice, Lepetre-Mouelhi, Sinda, Mougin, Julie, Parrod, Martine, Pieters, Grégory, Garcia-Argote, Sébastien, Loreau, Olivier, Goncalves, Jordan, Chacun, Hélène, Courbebaisse, Yann, Clayette, Pascal, Desmaële, Didier, Rousseau, Bernard, Andrieux, Karine, Couvreur, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Publishers 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534517/
https://ncbi.nlm.nih.gov/pubmed/26087468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.06.016
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