Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that Stx induced rapid reduction of short-lived anti-apoptotic proteins followed by activation of caspase 9 and the progression of apoptosis. Proteasome inhibitors prevented...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Hattori, Takayuki, Watanabe-Takahashi, Miho, Ohoka, Nobumichi, Hamabata, Takashi, Furukawa, Koichi, Nishikawa, Kiyotaka, Naito, Mikihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534485/
https://ncbi.nlm.nih.gov/pubmed/26273560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.06.005
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