An Orally Applicable Shiga Toxin Neutralizer Functions in the Intestine To Inhibit the Intracellular Transport of the Toxin

Shiga toxin 2 (Stx2) is a major virulence factor in infections with Stx-producing Escherichia coli (STEC), which causes gastrointestinal diseases and sometimes fatal systemic complications. Recently, we developed an oral Stx2 inhibitor known as Ac-PPP-tet that exhibits remarkable therapeutic potency...

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Autores principales: Watanabe-Takahashi, Miho, Sato, Toshio, Dohi, Taeko, Noguchi, Noriko, Kano, Fumi, Murata, Masayuki, Hamabata, Takashi, Natori, Yasuhiro, Nishikawa, Kiyotaka
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Microbial Immunity and Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798190/
https://ncbi.nlm.nih.gov/pubmed/19858299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01022-09
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