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Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation

The sliding clamp PCNA is a crucial component of the DNA replication machinery. Timely PCNA loading and unloading are central for genome integrity and must be strictly coordinated with other DNA processing steps during replication. Here, we show that the S. cerevisiae Elg1 replication factor C-like...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kubota, Takashi, Katou, Yuki, Nakato, Ryuichiro, Shirahige, Katsuhiko, Donaldson, Anne D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534484/
https://ncbi.nlm.nih.gov/pubmed/26212319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.066
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