Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression

Deficiency in DNA ligase I, encoded by CDC9 in budding yeast, leads to the accumulation of unligated Okazaki fragments and triggers PCNA ubiquitination at a non-canonical lysine residue. This signal is crucial to activate the S phase checkpoint, which promotes cell cycle delay. We report here that a...

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Detalhes bibliográficos
Main Authors: Nguyen, Hai Dang, Becker, Jordan, Thu, Yee Mon, Costanzo, Michael, Koch, Elizabeth N., Smith, Stephanie, Myung, Kyungjae, Myers, Chad L., Boone, Charles, Bielinsky, Anja-Katrin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688925/
https://ncbi.nlm.nih.gov/pubmed/23824283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066379
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