Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIV(mac251) Rectal Challenge

Many viral infections, including HIV, exhibit sex-based pathogenic differences. However, few studies have examined vaccine-related sex differences. We compared immunogenicity and protective efficacy of monomeric SIV gp120 with oligomeric SIV gp140 in a pre-clinical rhesus macaque study and explored...

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Udgivet i:PLoS Pathog
Main Authors: Tuero, Iskra, Mohanram, Venkatramanan, Musich, Thomas, Miller, Leia, Vargas-Inchaustegui, Diego A., Demberg, Thorsten, Venzon, David, Kalisz, Irene, Kalyanaraman, V. S., Pal, Ranajit, Ferrari, Maria Grazia, LaBranche, Celia, Montefiori, David C., Rao, Mangala, Vaccari, Monica, Franchini, Genoveffa, Barnett, Susan W., Robert-Guroff, Marjorie
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534401/
https://ncbi.nlm.nih.gov/pubmed/26267144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005101
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