Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIV(mac251) Rectal Challenge

Many viral infections, including HIV, exhibit sex-based pathogenic differences. However, few studies have examined vaccine-related sex differences. We compared immunogenicity and protective efficacy of monomeric SIV gp120 with oligomeric SIV gp140 in a pre-clinical rhesus macaque study and explored...

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Publicat a:PLoS Pathog
Autors principals: Tuero, Iskra, Mohanram, Venkatramanan, Musich, Thomas, Miller, Leia, Vargas-Inchaustegui, Diego A., Demberg, Thorsten, Venzon, David, Kalisz, Irene, Kalyanaraman, V. S., Pal, Ranajit, Ferrari, Maria Grazia, LaBranche, Celia, Montefiori, David C., Rao, Mangala, Vaccari, Monica, Franchini, Genoveffa, Barnett, Susan W., Robert-Guroff, Marjorie
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534401/
https://ncbi.nlm.nih.gov/pubmed/26267144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005101
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