Effect of IKZF1 deletions on signal transduction pathways in Philadelphia chromosome negative pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL)

BACKGROUND: IKZF1 deletions are an unfavorable prognostic factor in children with Philadelphia chromosome positive (Ph(+)) as well as negative (Ph(−)) acute lymphoblastic leukemia (ALL). Although IKZF1 deletions occur in 10–15% of Ph(−) ALL cases, effects of IKZF1 deletions on signaling pathways in...

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Vydáno v:Exp Hematol Oncol
Hlavní autoři: van der Sligte, Naomi E, Scherpen, Frank J G, ter Elst, Arja, Guryev, Victor, van Leeuwen, Frank N, de Bont, Eveline S J M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534008/
https://ncbi.nlm.nih.gov/pubmed/26269779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-015-0017-y
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