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SH3KBP1 binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex SHKBP1 prevents EGFR degradation by the interruption of c-Cbl-CIN85 complex

The binding of Cbl-interacting protein of 85 kDa (CIN85) to c-Cbl is important to endocytosis and degradation of epidermal growth factor receptor (EGFR). The proline-arginine motif PXXXPR in c-Cbl and SH3 domains of CIN85 are essential to this interaction. Here we demonstrated that SH3KBP1 binding p...

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Bibliografiske detaljer
Udgivet i:Cell Biochem Funct
Main Authors: Feng, Lifeng, Wang, Jin-Tao, Jin, Hongchuan, Qian, Kaixian, Geng, Jian-Guo
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534006/
https://ncbi.nlm.nih.gov/pubmed/21830225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbf.1792
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