Endothelial–cell FAK targeting sensitizes tumours to DNA–damaging therapy

Chemoresistance is a serious limitation of cancer treatment(1). Until recently, almost all the work done to study this limitation has been restricted to tumour cells(2). Here we identify a novel molecular mechanism by which endothelial cells regulate chemosensitivity. We establish that specific targ...

詳細記述

保存先:
書誌詳細
出版年:Nature
主要な著者: Tavora, Bernardo, Reynolds, Louise E., Batista, Silvia, Demircioglu, Fevzi, Fernandez, Isabelle, Lechertier, Tanguy, Lees, Delphine M., Wong, Ping–Pui, Alexopoulou, Annika, Elia, George, Clear, Andrew, Ledoux, Adeline, Hunter, Jill, Perkins, Neil, Gribben, John G., Hodivala–Dilke, Kairbaan M.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533916/
https://ncbi.nlm.nih.gov/pubmed/25079333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13541
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