FAK-heterozygous mice display enhanced tumour angiogenesis

Genetic ablation of endothelial Focal Adhesion Kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularisation. Here we show that reduced stromal-FAK expression in FAK-heterozygous mice unexpectedly enhances both B16F0 and CMT19T...

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Autores principales: Kostourou, Vassiliki, Lechertier, Tanguy, Reynolds, Louise E., Lees, Delphine M., Baker, Marianne, Jones, Dylan T., Tavora, Bernardo, Ramjaun, Antoine R., Birdsey, Graeme M., Robinson, Stephen D., Parsons, Maddy, Randi, Anna M., Hart, Ian R, Hodivala-Dilke, Kairbaan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712492/
https://ncbi.nlm.nih.gov/pubmed/23799510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3020
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