FAK-heterozygous mice display enhanced tumour angiogenesis

Genetic ablation of endothelial Focal Adhesion Kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularisation. Here we show that reduced stromal-FAK expression in FAK-heterozygous mice unexpectedly enhances both B16F0 and CMT19T...

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Bibliografiska uppgifter
Huvudupphovsmän: Kostourou, Vassiliki, Lechertier, Tanguy, Reynolds, Louise E., Lees, Delphine M., Baker, Marianne, Jones, Dylan T., Tavora, Bernardo, Ramjaun, Antoine R., Birdsey, Graeme M., Robinson, Stephen D., Parsons, Maddy, Randi, Anna M., Hart, Ian R, Hodivala-Dilke, Kairbaan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712492/
https://ncbi.nlm.nih.gov/pubmed/23799510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3020
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