Endothelial–cell FAK targeting sensitizes tumours to DNA–damaging therapy

Chemoresistance is a serious limitation of cancer treatment(1). Until recently, almost all the work done to study this limitation has been restricted to tumour cells(2). Here we identify a novel molecular mechanism by which endothelial cells regulate chemosensitivity. We establish that specific targ...

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Vydáno v:Nature
Hlavní autoři: Tavora, Bernardo, Reynolds, Louise E., Batista, Silvia, Demircioglu, Fevzi, Fernandez, Isabelle, Lechertier, Tanguy, Lees, Delphine M., Wong, Ping–Pui, Alexopoulou, Annika, Elia, George, Clear, Andrew, Ledoux, Adeline, Hunter, Jill, Perkins, Neil, Gribben, John G., Hodivala–Dilke, Kairbaan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533916/
https://ncbi.nlm.nih.gov/pubmed/25079333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13541
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