Endothelial–cell FAK targeting sensitizes tumours to DNA–damaging therapy

Chemoresistance is a serious limitation of cancer treatment(1). Until recently, almost all the work done to study this limitation has been restricted to tumour cells(2). Here we identify a novel molecular mechanism by which endothelial cells regulate chemosensitivity. We establish that specific targ...

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Veröffentlicht in:Nature
Hauptverfasser: Tavora, Bernardo, Reynolds, Louise E., Batista, Silvia, Demircioglu, Fevzi, Fernandez, Isabelle, Lechertier, Tanguy, Lees, Delphine M., Wong, Ping–Pui, Alexopoulou, Annika, Elia, George, Clear, Andrew, Ledoux, Adeline, Hunter, Jill, Perkins, Neil, Gribben, John G., Hodivala–Dilke, Kairbaan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533916/
https://ncbi.nlm.nih.gov/pubmed/25079333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13541
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