Probing the Hydrogen Bonding of the Ferrous–NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance

Oxidation of L-arginine (L-Arg) to nitric oxide (NO) by NO synthase (NOS) takes place at the heme active site. It is of current interest to study structures of the heme species that activates O(2) and transforms the substrate. The NOS ferrous–NO complex is a close mimic of the obligatory ferric (hyd...

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Publicado en:J Phys Chem A
Main Authors: Astashkin, Andrei V., Chen, Li, Elmore, Bradley O., Kunwar, Deepak, Miao, Yubin, Li, Huiying, Poulos, Thomas L., Roman, Linda J., Feng, Changjian
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533915/
https://ncbi.nlm.nih.gov/pubmed/26035438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpca.5b01804
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