Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition

Proteoglycan degradation contributing to the pathogenesis of intervertebral disc (IVD) degeneration is induced by inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Cell autophagy exists in degenerative diseases, including osteoarthritis and inter-vertebral d...

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Publicado no:Int J Mol Med
Main Authors: XU, KANG, CHEN, WEIJIAN, WANG, XIAOFEI, PENG, YAN, LIANG, ANJING, HUANG, DONGSHENG, LI, CHUNHAI, YE, WEI
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533778/
https://ncbi.nlm.nih.gov/pubmed/26165348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2015.2280
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