Enhanced astroglial GABA uptake attenuates tonic GABA(A) inhibition of the presympathetic hypothalamic paraventricular nucleus neurons in heart failure

γ-Aminobutyric acid (GABA) generates persistent tonic inhibitory currents (I(tonic)) and conventional inhibitory postsynaptic currents in the hypothalamic paraventricular nucleus (PVN) via activation of GABA(A) receptors (GABA(A)Rs). We investigated the pathophysiological significance of astroglial...

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Pubblicato in:J Neurophysiol
Autori principali: Pandit, Sudip, Jo, Ji Yoon, Lee, Sang Ung, Lee, Young Jae, Lee, So Yeong, Ryu, Pan Dong, Lee, Jung Un, Kim, Hyun-Woo, Jeon, Byeong Hwa, Park, Jin Bong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
Soggetti:
Nervous System Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533111/
https://ncbi.nlm.nih.gov/pubmed/26063771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00080.2015
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