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Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice

The male’s ability to reproduce is completely dependent on Sertoli cells. However, the mechanisms governing the functional integrity of Sertoli cells have remained largely unexplored. Here, we demonstrate that deletion of Shp2 in Sertoli cells results in infertility in mice. In Shp2 knockout mice (S...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Hu, Xiaopeng, Tang, Zhenzhou, Li, Yang, Liu, Wensheng, Zhang, Shuang, Wang, Bingyan, Tian, Yingpu, Zhao, Yinan, Ran, Hao, Liu, Wenjie, Feng, Gen-Sheng, Shuai, Jianwei, Wang, Haibin, Lu, Zhongxian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533007/
https://ncbi.nlm.nih.gov/pubmed/26265072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12982
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