Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice

The male’s ability to reproduce is completely dependent on Sertoli cells. However, the mechanisms governing the functional integrity of Sertoli cells have remained largely unexplored. Here, we demonstrate that deletion of Shp2 in Sertoli cells results in infertility in mice. In Shp2 knockout mice (S...

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Vydáno v:Sci Rep
Hlavní autoři: Hu, Xiaopeng, Tang, Zhenzhou, Li, Yang, Liu, Wensheng, Zhang, Shuang, Wang, Bingyan, Tian, Yingpu, Zhao, Yinan, Ran, Hao, Liu, Wenjie, Feng, Gen-Sheng, Shuai, Jianwei, Wang, Haibin, Lu, Zhongxian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533007/
https://ncbi.nlm.nih.gov/pubmed/26265072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12982
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