Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers

Triple-negative breast cancer (TNBC), which is closely related to basal-like breast cancer, is a highly aggressive subtype of breast cancer that initially responds to chemotherapy but eventually develops resistance. This presents a major clinical challenge as there are currently no effective targete...

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Udgivet i:Am J Transl Res
Main Authors: Yang, Cheng-Chieh, LaBaff, Adam, Wei, Yongkun, Nie, Lei, Xia, Weiya, Huo, Longfei, Yamaguchi, Hirohito, Hsu, Yi-Hsin, Hsu, Jennifer L, Liu, Dongping, Lang, Jingyu, Du, Yi, Lien, Huang-Chun, Li, Long-Yuan, Deng, Rong, Chan, Li-Chuan, Yao, Jun, Kleer, Celina G, Hortobagyi, Gabriel N, Hung, Mien-Chie
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532735/
https://ncbi.nlm.nih.gov/pubmed/26279746
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