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Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice
Charcot-Marie-Tooth disease type 1A (CMT1A) is a hereditary peripheral neuropathy characterized by progressive demyelination and distal muscle weakness. Abnormal expression of peripheral myelin protein 22 (PMP22) has been linked to CMT1A and is modeled by Trembler J (TrJ) mice, which carry the same...
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| Publié dans: | Neurobiol Dis |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4532623/ https://ncbi.nlm.nih.gov/pubmed/25014022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.06.023 |
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