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A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges

Biophysical models of cardiac tension development provide a succinct representation of our understanding of force generation in the heart. The link between protein kinetics and interactions that gives rise to high cooperativity is not yet fully explained from experiments or previous biophysical mode...

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Publicado en:PLoS Comput Biol
Autores principales: Land, Sander, Niederer, Steven A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532474/
https://ncbi.nlm.nih.gov/pubmed/26262582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004376
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